WebMoreover, increase in phosphorylated ERK1/2 and CREB levels and melanogenesis-specific molecules is induced by mutated SASH1 alleles. Together, our results suggest that a novel SASH1/MAP2K2 crosstalk connects ERK1/2/CREB cascade with p53-POMC-MC1R cascade to cause hyperpigmentation phenotype of DUH. Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during … See more POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged in large dense-core vesicles that are released from the cells by exocytosis in response to appropriate stimulation: See more The large molecule of POMC is the source of several important biologically active substances . POMC can be cleaved enzymatically into the following peptides: • See more A deletion mutation common in Labrador Retriever and Flat-Coated Retriever dogs is associated with increased interest in food and subsequent obesity. See more The POMC gene is located on chromosome 2p23.3. The POMC gene is expressed in both the anterior and intermediate lobes … See more The levels of proopiomelanocortin (pomc) are regulated indirectly in some animals by the photoperiod. It is referred to the hours of light during a day and it changes across the seasons. Its … See more Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. A study concluded … See more POMC is used as a target for a medication used to treat obesity in humans. The combination of bupropion and naltrexone acts via hypothalamic POMC neurons to decrease appetite. See more

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 …

WebFeb 13, 2009 · Although considered a significant psychosocial distress, little is known about the detailed mechanisms of hyperpigmentation. Recently, the tumor suppressor protein … Weba novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. Data suggest … high school geometry final test

p53 regulates ERK1/2/CREB cascade via a novel SASH1/MAP2K2 …

WebHistologic and electron paramagnetic resonance spectrometry examination demonstrated that hair follicles in back skin of Pomc-/- mice developed with normal structure and … WebJun 9, 2024 · Proopiomelanocortin (POMC) deficiency is an extremely rare inherited autosomal recessive disorder characterized by severe obesity, adrenal insufficiency, skin … WebP53 directly controls the POMC/α-MSH productions induced by ultraviolet (UV) ... A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause … high school geometry curriculum homeschool