WebbThe amphiphilic prodrugs form self-assembled nanoparticles in deionized water and encapsulate the hydrophobic anticancer drug 10-hydroxycamptothecin (HCPT) with a high drug loading efficiency. WebbConventional nanoparticulate drug delivery systems of paclitaxel (PTX) are challenged with low drug loading efficiency and potential biomaterials-induced toxicity. In this work, novel star-shape PTX prodrugs modified by vitamin E succinate with a load of double PTX molecules via carbonate (PC) or succinate (PE) as
A Smart Nano‐Prodrug Platform with Reactive Drug Loading, …
Webb20 sep. 2024 · Prodrug entrapment into nanocarriers for tumor delivery is a strategy to achieve a valid therapy with high efficiency. The prodrug contains anticancer agents conjugating with functional moieties or ligands so that the active component is released after metabolism in the body or tumor. The advantages of nanosystems for loading … Webb19 nov. 2024 · PEGylated Doxorubicin Prodrug-Forming Reduction-Sensitive Micelles With High Drug Loading and Improved Anticancer Therapy. Dongdong Wang Minimally Invasive Interventional Therapy Center, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, China. Search articles by 'Dongdong Wang' Wang D1, Xiaoyi Zhang hornet\\u0027s nest elementary school
Quantitative and high drug loading of self-assembled …
Webb10 aug. 2024 · Nanomedicines have made significant progress in the delivery of small molecular drugs, many challenges, however, still remain to be overcome, such as … Webb20 dec. 2012 · Innovative strategies to improve the drug loading and reduce nontherapeutic contents of DDS have been developed recently by researchers, where the drug was coupled, via cleavable bonds, with... Webb4 nov. 2024 · Here, we report that simple insertion of a trisulfide bond can turn doxorubicin homodimeric prodrugs into self-assembled nanoparticles with three benefits: high drug … hornet\u0027s nest elementary school